Longevity Medicine
Longevity Medicine
DHEA for Androgen Deficiency May Offer Positive Skin Effects
Dehydroepiandrosterone, which many women take as an antiaging supplement, may indeed produce thicker, suppler skin, according to a double-blind, randomized trial of therapy for women with severe androgen deficiency due to hypopituitarism
Feb 23, 2003, 1:40pm

Longevity Medicine
Mass Market Age Mitigation?
Nestle, the Swiss consumer products company, has just been applied for a patent for a food and supplement formulation that (the patent application suggests) reverses many of the effects of aging, and extends both healthspan and longevity of animals (and likely humans).
Dec 15, 2002, 12:39pm

Longevity Medicine
Insulin-Like Growth Factor 1 and Mammalian Aging
Insulin-like growth factor 1 (IGF-1) is produced in many organs in response to growth hormone (GH), which is secreted by the pituitary. IGF-1 serves as a key mediator of GH actions (Fig. 1). Studies in genetically altered mice have provided strong evidence that alterations in GH signaling and therefore in the resulting IGF-1 production can delay aging and prolong life. Five genetic alterations--either spontaneous mutations at a single locus or targeted disruption ("knockout") of a single gene--lead to major extensions of life-span in mice (1-4) (Fig. 2). Three of these five types of genetically long-lived mice are GH-deficient [Ames dwarf mice, which carry a mutation in the prop-1 gene (5), Snell dwarf mice, which carry a mutation in the pit-1 gene (6), and Little mice, which carry a mutation in the Ghrhr gene (7)], and one is GH-resistant [GH receptor gene knockout or Laron mice (8)]. All of these defects lead to the profound suppression of IGF-1 concentration in the peripheral circulation (Fig. 1) [for review, see (9, 10)]. The fifth mouse contains a mutation in the p66shc gene. Visit Website ]
Nov 30, 2002, 12:29pm

Longevity Medicine
Aging: A Theory Based on Free Radical and Radiation Chemistry
Copyright (c) The Gerontological Society of America
This 1956 paper describes a theory about mechanisms of aging that is based on free radical chemistry: "Aging and the degenerative diseases associated with it are attributed basically to the deleterious side attacks of free radicals on cell constituents and on the connective tissues. The free radicals probably arise largely through reactions involving molecular oxygen catalyzed in the cell by oxidative enzymes and in the connective tissues by traces of metals such as iron, cobalt, and manganese."

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Nov 30, 2002, 12:03pm

Longevity Medicine
Lean, Yes--But Mean? Growth hormone thins and strengthens the elderly, but at a cost
Growth hormone (GH) rewinds the years, countless supplement-peddling Web sites proclaim. But scientific evidence of the molecule's benefits remains scant, and the risks of long-term GH therapy are unknown. According to a new study, GH reduces fat and increases muscle in older people, and it might make them stronger and more fit. Frequent side effects, however, indicate that GH therapy still faces considerable growing pains.


Nov 30, 2002, 9:01am

Longevity Medicine
To Blackman et al, "Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men,"
The American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net) has reviewed the findings of the Blackman et al (2002) study published in the November 13, 2002 issue of the Journal of the American Medical Association (JAMA). The position of the A4M on the Blackman et al study is as follows

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Nov 13, 2002, 6:38pm

Longevity Medicine
Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men
JAMA. 2002;288:2282-2292
Hormone administration to elderly individuals can increase lean body mass (LBM) and decrease fat, but interactive effects of growth hormone (GH) and sex steroids and their influence on strength and endurance are unknown

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Nov 13, 2002, 6:34pm

Longevity Medicine
DHEA for Depression and Dementia
The supplement DHEA is touted as a “superhormone” that can slow aging, “melt away disease,” and improve strength.

Investigational medical uses include depression and dementia; the data thus far have been mixed, and long-term effects are unknown.

Nov 12, 2002, 8:34pm

Longevity Medicine
Take multivitamins, AMA urges in policy reversal
Reversing a long-standing anti-vitamin policy, The Journal of the American Medical Association today is advising all adults to take at least one multivitamin pill each day.
Aug 31, 2002, 11:09pm

Longevity Medicine
Melatonin deficiencies in women
Melatonin seems to be the natural hormone to facilitate sleep in insomniac patients and causes no hang over. When applied together with benzodiazepine it allows reduction of benzodiazepine without withdrawal effects.
Aug 22, 2002, 10:14pm


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DHEA for Androgen Deficiency May Offer Positive Skin Effects
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