Menopause
Menopause
Topical Estrogen
The basis for topical estrogen study stems from the findings of a correlation between natural estrogen depletion and chronologic aging, especially aging of the skin.

Estrogen is a dynamic hormone that is matched with an equally impressive array of exogenous replacement products. The family of estrogen products includes estrogens in conjugated or esterified forms, ethinyl estradiols, estradiols, estradiol derivatives such as estradiol valerate and estradiol cypionate, estriols, and estrones

Mar 13, 2003, 10:00pm

Menopause
The timing of hormone replacement therapy could be key to success
The timing of treatment may be a key factor in whether hormone replacement therapy (HRT) can slow heart vessel disease, report researchers from Wake Forest University Baptist Medical Center and Tufts-New England Medical Center in the winter issue of Menopausal Medicine.
Mar 3, 2003, 10:31pm

Menopause
Transdermal Estradiol May Be an Effective Antidepressant in Perimenopausal Women
Transdermal estradiol appears to be an effective antidepressant in perimenopausal women with various forms of depression.
Mar 2, 2003, 7:11pm

Menopause
HRT May Cut Risk of Type 2 Diabetes by 35% Still overshadowed by rise in adverse events.
Hormone replacement therapy has been shown to prevent the development of type 2 diabetes in a large, randomized, double-blind, placebo-controlled trial of postmenopausal women with coronary heart disease.


Mar 2, 2003, 7:03pm

Menopause
Making decisions about hormone replacement therapy
Women are increasingly encouraged to participate in making decisions about hormone replacement therapy. However, the complexity and uncertainty of information about the treatment can make it difficult for women to make a decision, increasing their reliance on medical advice.4 The publication of the heart and oestrogen-progestin replacement study (HERS)5 and women's health initiative (WHI)6 study, both of which found adverse effects, has added to the confusion. In this article, we define who should be offered hormone replacement therapy and why, describe the reasons why women may wish to take hormone replacement therapy, and clarify the advantages and disadvantages of treatment.
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Feb 9, 2003, 8:40pm

Menopause
Discussing breast cancer and hormone replacement therapy with women
Although the results of the Women’s Health Initiative showed an increased risk of breast cancer in women taking
hormone replacement therapy (HRT), the absolute risk is very low. We discuss limitations of the study,
questions that remain, and how to discuss the study with women at average risk and high risk for breast cancer.

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Dec 22, 2002, 9:13pm

Menopause
Management of perimenopause:Focus on alternative therapies
Cleveland Clinic Journal of Medicine
A variety of herbs and other “natural alternative medicines” are marketed directly to consumers and sold
over-the-counter as treatments for perimenopausal symptoms. Far from being innocuous placebos, many of these substances have real physiologic effects, including potential adverse effects and drug interactions. Yet they are largely untested and, by law, totally unregulated.
This article reviews a few of the untested substances your patients may be taking, along with established treatments.

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Nov 15, 2002, 9:46pm

Menopause
Pathophysiology and Treatment of Hot Flashes
Mayo Clinic Proceedings
Hot flashes affect about three fourths of postmenopausal
women and are one of the most common health problems in this demographic group. Dysfunction of central thermoregulatory centers caused by changes in estrogen levels at the time of menopause has long been postulated to be the cause of hot flashes.

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Nov 13, 2002, 6:20pm

Menopause
Pilot Evaluation of Gabapentin for Treating Hot Flashes
Mayo Clinic Proceedings
Data from 20 women in this pilot study suggest that gabapentin is reasonable treatment to consider in patients with hot flashes who do not want to use hormonal therapy. However, a double-blind placebo-controlled clinical trial should be conducted to better elucidate the efficacy and toxic effects of gabapentin.

http://www.mayo.edu/proceedings/2002/nov/7711a1.pdf
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Nov 13, 2002, 6:16pm

Menopause
Hot Flashes: The Old and the New, What Is Really True?
Mayo Clinic Proceedings
Estradiol levels decline intermittently during the perimenopausal transition and permanently after menopause.
As a consequence, women experience symptoms related to urogenital atrophy, vasomotor instability, neurocognitive
dysfunction, accelerated bone loss, and cardiovascular
disease. For some women, vasomotor instability and associated insomnia are disabling.

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Nov 13, 2002, 5:54pm


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